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Activated with the antibiotic rifampicin and a variety of plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to unique ligands is species-distinct. Activated by Normally developing steroids, for example pregnenolone and progesterone. Binds to some reaction component inside the promoters in the CYP3A4 and ABCB1/